Page 18 - MaquetaFundCIEN-2019-ENG

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Annual Report 2019
of interest, fatigue, illness, change of address, death, etc.), in order to enhance all the work already carried out (once the epidemiological situation makes it possible to resume the follow-up visits safely), in the short term it is proposed to recover the largest possible number of volunteers for at least one last visit, so that their evolution can be recorded, especially in the area of cognition. Likewise, given that one of the limitations of the cohort is the lack of cerebrospinal fluid biomarkers (the protocol does not include performing lumbar punctures) that allow us to increase the precision of clinical diagnoses, the measurement of dis- ease markers is proposed in blood using ultrasensitive cutting-edge techniques. All of this will allow us to continue with the definition of markers of Alzheimer’s disease with greater precision and scientific relevance.
Finally, it is worth highlighting another important ramification of the current study of this cohort that is related to the low rate of conversion to dementia observed throughout the eight years of development of the project, and the supra-normal- ization of the cohort. In this sense, a study of “superagers” is being carried out, focused on determining the factors of resilience to neurodegeneration.