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Future lines of research
Using the available data from the Vallecas Project, at least five studies are pro- posed that already have produced preliminary results:
• Study of the variables associated with the reversion of the MCI state to that of cognitive normality. The objective of this work is to identify those lifestyle variables that could be playing an essential role in the reversion and, later, propose possible interventions on them in another sample of subjects.
• Obtain a probabilistic and predictive algorithm, through the use of artificial in- telligence techniques, that allows quantifying the risk of developing cognitive impairment in the short and medium term. This algorithm will allow the identi- fication of subjects at risk of conversion at least 5 years before the evolution takes place. Consequently, it is expected to be able to intervene on these sub- jects through interventions of all kinds in order to prevent or modify the course of the disease.
• Analysis of discrepancies and unreliability in the collection of educational lev- el within the Vallecas Project. Fortuitously, the self-reported data regarding the educational level of the subjects has been collected during three consec- utive visits to the Vallecas Project. The results show a completely unexpected finding: the reliability in the collection of this variable, which is highly relevant in this field, is highly questionable since 1 in 3 subjects do not report consist- ently on their actual educational level.
• Longitudinal normative data and reliable change index in a selection of cog- nitive tests from the Vallecas Project. To carry out this work, we will collabo- rate with partners of the consortium that emerged under the project financed within the 2018 call of the National Plan.
• Study of the association between SCI-Plus and functional connectivity meas- ured through fMRI. Over the last few years we have repeatedly requested ac- cess to neuroimaging data from both the head of the department and the PI of the Vallecas Project. Despite the fact that this access has never material- ized, in the neuropsychology department we do not lose hope of being able to carry out this study that can have a high impact: there are hardly any similar studies in the scientific literature, and much less considering that we have longitudinal data.
Team
Miguel Ángel Fernández Blázquez (Dr. Psychology, Neuropsychology). Head of Neuropsychology.
Marina Ávila Villanueva (Dr. Psychology, Neuropsychology).
Belén Frades Payo (Grad. Psychology, Neuropsychology).
NEUROLOGY-NEUROPSYCHOLOGY ADMINISTRATION
Francisca Martínez Lois (Administrative Assistant) Beatriz Salado Martínez (Administrative Assistant)
3. Scientific activity
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