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Annual Report 2019
velopment of a non-genetic test adapted to the hospital diagnostic routine for measuring blood ApoE4 as a marker for determining the AD risk and that has cur- rently obtained the CE label.
Other collaborations
• Assessment of lactoferrin levels in saliva as a marker of Alzheimer’s disease in collaboration with Drs. Eva Carro and Félix Bermejo from the 12 de Octubre Hos- pital
• Study of the role of lipofuscin in neurodegeneration in collaboration with Dr. A Kun from the University of the Republic, Uruguay
• Study of the participation of the Aß peptide in gliogenesis and proliferation in human neural stem cells with Dr. I. Liste from the Carlos III Health Institute.
Contribution to BT-CIEN
The Biochemistry and Molecular Genetics department also contributes to the BT- CIEN with processing of various samples, and collaborates on several external projects focused on Alzheimer’s disease and other neurodegenerative diseases.
In the context of research focused on the study of biomarkers and genetic sus- ceptibility factors, the UIPA Laboratory department is responsible for collecting, processing and storing biological samples for research related to various projects or for its deposit in the BT CIEN, whose ultimate purpose is to use in different re- search areas on neurodegenerative diseases.
Currently, the department contributes to BT-CIEN with various biological samples including 520 CSF samples from donor’s brain, 315 skin samples, and 258 saliva samples.
Biochemistry and Molecular Genetics Team.