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  tional analytics. Thus, performing a venipuncture in the patient for research pur- poses only is avoided. After extraction, each blood sample is processed at once, resulting in 14 aliquots comprising various hematologic derivatives (whole blood, plasma, serum, etc.), including extraction of DNA for genetic studies.
Aliquots obtained from blood samples are incorporated into the CIEN Tissue Bank (BT-CIEN, for its acronym in Spanish) collection according to the protocols of the biobank. The total number of samples incorporated to the BT-CIEN so far, corre- sponding to the Alzheimer project monitoring program, adds up to 2,420 (14.0% pa- tients corresponding to the Day Centre), which have resulted in a total of 33,880 aliquots of different fractions derived from blood samples.
3. Scientific activity
69
   2019
                        EVALUATION
Residence
Day Center
 1a
16
1
    2a
24
5
    3a
19
2
  4a
18
0
    5a
33
9
  6a
16
3
     7a
6
2
  8a
7
1
  9a
11
1
    10a
8
0
  11a
7
0
     12a
8
0
  13a
3
1
  14a
3
0
    15a
1
0
  16a
1
1
    17a
2
  18a
1
     T
184
26
                                      ACUMULATED
                        EVALUATION
Residence
Day Center
 1a
349
133
    2a
320
102
    3a
281
77
  4a
234
58
    5a
224
44
  6a
178
29
     7a
154
15
  8a
142
10
  9a
141
6
    10a
128
4
  11a
97
4
     12a
88
4
  13a
72
3
  14a
68
1
    15a
45
1
  16a
39
1
    17a
35
0
  18a
27
0
     19a
202
26
  20a
14
0
  21a
8
0
     22a
2
0
   TOTAL
2848
518
  Samples obtained up to December 31, 2019 according to the number of semiannual evaluations. Above: samples obtained in 2019. Below: samples accumulated since the beginning of the CAFRS Research program
       Consistent with other studies, the analysis of the APOE gene polymorphism in CA- FRS patients revealed a high presence of allele ε4, which in this population ap- pears to be more prevalent in men. In addition, the phenomenon of advancement of the age of onset of Alzheimer’s disease associated with the ε4 allele observed in other cohorts, is noted, as it is the reverse phenomenon of delayed age of onset associated with the ε2 allele.
Distribution of APOE genotypes in the CAFRS patients cohort
  APOE GENOTYPES
   N
 e2/e2
  0
 e2/e3
    19
 e2/e4
  5
 e3/e3
   214
 e3/e4
   168
 e4/e4
   35
    

       

     

     

       

         

           

             
             
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