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• Other relevant systemic diseases: hepatic failure, renal failure, Obstructive Sleep Apnea Syndrome (OSA)
• Family history with special attention to the history of dementia or movement disorders, developmental delay or psychiatric disorders.
• Regular drug treatment during the last 5 years.
• From 207 to 2019, all volunteers who consent to carry an accelerometer device
(Actigraph®), similar to a wrist watch, are being provided with it for the record- ing of physical activity and sleep for a week. During that period, the following records have been registered:
− 2017: 251 records − 2018: 375 records − 2019: 181 records
Distributed as follows:
− Volunteers with only 1 record: 249 − Volunteers with 2 records: 262
− Volunteers with 3 records: 12
Hence, we have a sample size of 523 volunteers with at least one record already registered, and 274 volunteers with a second record after one year follow up.
This information must be processed to obtain a number of variables related to light, moderate or intense activity, as well as indicators of sleep duration and pat- tern.
4.3.4. General examination
All subjects undergo a general and neurological standard examination: cranial nerves, muscle balance, coordination, extrapyramidal system, gait, osteotendi- nous reflexes, midline release reflexes, etc. The following parameters are analyzed in a special way:
• Gait disturbance
• Handwriting
• Instrumental activities of daily living
4.3.5. Neuropsychological Examination
The neuropsychological evaluation allows to explore in a holistic way the various cognitive domains (gnosias, attention, memory, language, praxis and executive functions), as well as a series of variables related to affectivity, behavior and level of autonomy in the daily life of an individual. To do this, the neuropsycholo- gist can use different assessment instruments, including clinical interviews, be- havioral observation, cognitive tests and different questionnaires that allow for collecting information from both the individual and a reliable informant.
4. The Vallecas Project
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