Page 63 - Memora anual Fundación CIEN 2015
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3. SCIENTIFIC ACTIVITY
• Develop a new "ultra-compact" Raman-laser wing the development of a diagnostic system for a
technology equipment, specifically designed for socially very relevant disease like Alzheimer's.
marketing in vitro diagnostics (clinical analysis
laboratories, hospitals, etc.). In connection with the study of biomarkers and the
collaborative context with Biocross as well as various
The combination of a new system (with unique fea- Spanish hospitals, this year we have published an im-
tures by leveraging the know-how of previous deve- portant metabolomic study in plasma of people with
lopments in the field of the aerospace industry) Alzheimer's disease, mild cognitive impairment, or
along with the validation of Raman-laser spectros- with no cognitive dysfunction. The obtained results
copy-based diagnostic markers represents an op- show the possibility of classifying cases and controls
portunity to enter a solution in the market for through a blood sample with high accuracy, even
innovative diagnostics and clearly differentiated at early stages of the disease. These results are now
from the competition. in the process of validation in a larger multicenter
and international cohort.
This project builds on the Biocross's and CIEN Foun-
dation's experience in developing biomarkers for the Within the framework of CIBERNED cooperative pro-
diagnosis of Alzheimer's disease. This innovative pro- ject SIGNAL led by Dr. Alberto Lleó, this year we have
ject will create a multidisciplinary platform where also published a paper in which we have been able
companies and research centers join together, allo- to identify new AD markers, and to suggest that in-
Samples of cerebrospinal fluid (CSF) obtained post-mortem since 2008
80
60 61
55 57
40 38 38
2011
20 11 33 2012 2013 2014 2015
4 2009 2010
0 2008
CIEN Foundation Annual Report 2015 / 65
