Page 72 - Memora anual Fundación CIEN 2017
P. 72
The Department also participates in numerous colla- sample from human or animal origin. All the services
borations in external research projects, mainly with provided by the BT-CIEN are accessible to donors
CIBERNED research groups, and carries out its own in- and researchers through the website.
ternal projects, mainly based on series of cases from
post mortem donation. Among the active lines of re- • Performing neuropathological autopsies in brain
search in the Department are the following: tissue donors, both in the Region of Madrid and
neighboring Regions, as well as in other Regions
• Neuropathological and molecular study of that do not have a brain bank.
tauopathies, including Alzheimer's disease.
Pathogenic significance and spread of • Management of a biobank of neurological
associated cellular lesions. Argyrophilic grains samples. Transfer of samples to researchers
disease as a model of tauopathy with according to the BT-CIEN standard operating
predominant involvement of the medial protocols.
temporal lobe.
• Prospective collection of special biological
• Clinicopathological profiles in advanced samples for research projects, at the request of
dementia. Characterization of the combined the researchers, once approved in compliance
and mixed pathology and its impact on the with BT-CIEN protocols (and by the scientific and
clinical trajectories of the patients, with special ethical external committees).
attention to disease progression rate and
survival time. • Diagnostic consultations of neuropathological
cases. Among the external consultations, those
• Pathological role of fungal colonization and the carried out as support of other biobanks of
polymicrobial infection of the Central Nervous neurological samples with which BT-CIEN
System in Alzheimer-type pathology. Risk factors maintains a regular collaboration (Murcia,
and clinical impact. Salamanca, Leon and Cordoba) stand out.
Consultations are also received from different
• Distinctive features of Alzheimer-type pathology public hospitals and from the Anatomical
in nonagenarians and centenarians. Forensic Institute of Madrid
Neuropathological findings in subjects without
cognitive disorder above 90 years of age. • Performing neurohistological and
immunohistochemical techniques in
• Characterization and pathogenic study of neurological samples of human and
dementia-associated hippocampal sclerosis. experimental origin.
• Advance age-associated changes in Central • Incorporation in the biobank of samples
Nervous System and cerebral pathology in collections (usually, biological fluids, blood and
mammals and non-human primates. Search for CSF) from clinical research projects.
natural models of Alzheimer in primates and
other mammalian groups. • Organization of informative lectures and visits to
the biobank for the dissemination and
Provision of services promotion of brain tissue donation among
patients and relatives, health professionals and
The range of activities undertaken by the depart- the general population.
ment derives from the ability of its members to co-
llect, process, evaluate and diagnose brain tissue
CIEN Foundation Annual Report 2017 / 72
