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bilistic algorithm to identify individuals at risk for AD- neurological diseases (e.g. schizophrenia, stroke, se-
type dementia over the course of a few years. Such vere head trauma, Central nervous system infec-
an algorithm will be based on a combination of tions, uncorrected vitamin deficiencies, etc.).
socio-demographic, historical, clinical, neurological
and neuropsychological, biological (from blood In the table below some global data from the co-
tests) and neuroimaging (various forms of 3T MRI). hort of approximately 1,213 individuals evaluated to
date are indicated.
The participant recruitment phase for the Vallecas
project lasted from October 2011 to December 4.3.2. Sociodemographic profile
2013. By then, 1,213 individuals of both genders,
aged 70-85 years were recruited and evaluated at The following variables are collected through semi-
baseline. Once included in the study, the project structured interview: gender, date of birth, marital
conducts an annual follow-up for five years in order status, number of children, type and amount of in-
to assess the evolution profile of all participants, spe- come, primary occupation and education level,
cifically identifying those that develop cognitive im- hobbies and leisure activities, etc.
pairment and/or dementia. At the end of 2016, we
are at the end of the fourth visit for the entire cohort, In addition, each year volunteers also must com-
about the middle of the fifth visit and just starting the plete a scale of quality of life and subjective well-
sixth one (see figure in section 1.6 of this Report). being (mobility, personal care, daily activities,
pain/discomfort, anxiety/depression, and perceived
4.3.1. Baseline evaluation health status) as well as various questionnaires to ga-
ther information related to lifestyle.
Before entering the study, volunteers interested in
participating in it were subjected to an initial assess- 4.3.3. Clinical evaluation
ment to determine whether they meet the criteria
for inclusion and/or whether an exclusion criterion At each visit relevant information is collected from
exists. Overall, all volunteers were required to meet each volunteer by applying a semi-structured clini-
four inclusion criteria in order to be considered for cal interview:
entering the study:
• Vascular risk factors: blood pressure, diabetes
• Signing an informed consent. mellitus, smoking, heart disease, stroke
• Be aged between 70 and 85 years old.
• Availability and ability to reach the Alzheimer • Neurological history: mental retardation,
head injuries, etc.
Centre for visits.
• Visual and hearing abilities that allow • Consumption and/or toxic addiction:
alcoholism/level of regular alcohol intake,
conducting the study tests. addiction/consumption of other psychotropic
substances.
In addition, a number of exclusion criteria were es-
tablished, including the following: i) suspected or • Psychiatric pathology: depression, dysthymia,
diagnosed dementia; ii) inability to perform neuroi- bipolar disorder, psychotic disorders, anxiety
maging studies; iii) alcohol abuse; iv) mental retar- syndromes.
dation; or v) history of certain psychiatric or
CIEN Foundation Annual Report 2017 / 92
