Page 52 - Annual Report 2018

neuropathological diagnostic work and the mana- associated with dementia and Lewy pathology
gement of biological samples. limited to the amygdala.

The Department also participates in numerous colla- • Advance age-associated changes in Central
Nervous System and cerebral pathology in
borations in external research projects, mainly with CI-
mammals and non-human primates. Search for
BERNED research groups, and carries out its own
natural models of Alzheimer in primates and
internal projects, mainly based on series of cases from
other mammalian groups.
post mortem donation. Among the active lines of re-
search in the Department are the following:
Provision of services
• Neuropathological and molecular study of
tauopathies, including Alzheimer's disease. The range of activities undertaken by the depart-
Pathogenic significance and spread of ment derives from the ability of its members to co-
associated cellular lesions. Argyrophilic grains llect, process, evaluate and diagnose brain tissue
disease and other recently described sample from human or animal origin. All the services
tauopathies (PART, ARTAG) as models of provided by the BT-CIEN are accessible to donors
tauopathy with predominant involvement of the and researchers through the website.
medial temporal lobe.
• Performing neuropathological autopsies in brain
• Clinicopathological profiles in advanced tissue donors, both in the Region of Madrid and
dementia. Characterization of the combined neighboring Regions, as well as in other Regions
and mixed pathology and its impact on the that do not have a brain bank.
clinical trajectories of the patients, with special
attention to disease progression rate and • Management of a biobank of neurological
survival time (project based mainly on the samples. Transfer of samples to researchers
patient cohort from the residency of the Queen according to the BT-CIEN standard operating
Sofia Foundation Alzheimer's Center Research protocols together with biobank external
Program). committees.

• Pathological role of fungal colonization and the • Prospective collection of special biological
polymicrobial infection of the Central Nervous samples for research projects, at the request of
System in Alzheimer-type pathology. Risk factors the researchers, once approved in compliance
and clinical impact. with BT-CIEN protocols (and by the scientific and
ethical external committees).
• Distinctive features of Alzheimer-type pathology
in nonagenarians and centenarians. • Diagnostic consultations of neuropathological
Neuropathological findings in subjects without cases. Among the external consultations, those
cognitive disorder above 90 years of age. carried out as support of other biobanks of
neurological samples with which BT-CIEN
• Clinical-pathological and molecular maintains a regular collaboration (Murcia,
characterization of other focal Salamanca, Leon and Cordoba) stand out.
neurodegenerative pathologies (in addition to Consultations are also received from different
tauopathies) with a predominance in the public hospitals and from the Anatomical
medial temporal lobe: hippocampal sclerosis Forensic Institute of Madrid

CIEN Foundation Annual Report 2018 / 52