Page 54 - Annual Report 2018

Castilla y León (BTN-CyL) and the of Queen Sofia Uni- that obtained in 2017. As in the previous year, the in-
versity Hospital Biobank from Cordoba are active crease in donations from the Internal Donation Pro-
examples of this commitment. gram is noteworthy, with 152 total donations until the
end of 2018.
In 2013, the BT-CIEN has been accredited by the
Council of Health of the Region of Madrid, accor- Regarding the cases accumulated since the begin-
ding to what is established in the Royal Decree ning of BT-CIEN activity, the distribution by main neu-
1716/2011 on Biobanks, and registered in the Natio- ropathological diagnosis is the one shown in the
nal Registry of Biobanks of the Carlos III Institute of following figure, with approximately 50% of Alzhei-
Health. mer's cases, and extensive representation of the rest
of neurodegenerative diseases.
In January 2014 the Biobanks National Network Plat-
form (PRNBB, for its acronym in Spanish), promoted The research centers that have received samples
and funded by the Carlos III Institute of Health (2014- from BT-CIEN during 2018 have been:
2017) was constituted, with participation of the main
biobanks in the country, both hospital and non-hos- • Karolinska Institutet. Center for Alzheimer
pital, including BT-CIEN. PRNBB mission is to create a Research (Estocolmo)
stable organizational structure that allows the coor- • Research Functional Unit in Chronic diseases,
dinated activity of participating biobanks in the co- ISCIII, Madrid.
llection, management and transfer of biological • Medical School, University of La Laguna,
samples of human origin. Before concluding its pe- Tenerife,
riod of activity in December 2017, the PRNBB rene- • Medical School, University of Castilla-La
wed its commitment to the ISCIII for a new funding Mancha, Ciudad Real
period, 2018-2020. The BT-CIEN has played a promi- • Cajal Institute, CSIC
nent role in the R&D&I Program of the PRNBB and in • Center for Molecular Biology “Severo Ochoa”,
the new phase of the platform, initiated in January CSIC, Madrid
2018, has assumed the coordination tasks of the • Institute of Biomedical Research "Alberto Sols"
R+D+i program as a whole. Moreover, since 2012 the • Oslo University Hospital
BT-CIEN has the ISO 9001/2008 quality certification, • 12 de Octubre Hospital Research Institute
renewed in 2016, and that was also renewed in 2018 • Center of Applied Mecial Research (CIMA),
under the ISO 9001/2015 standard. University of Navarra
• Royal College of Surgeons in Ireland
The BT-CIEN registry had 660 registered donors by De- • Univesität Göttingen, Deutsches Zentrum für
cember 31, 2018. Neurodegenerative Erkrankungen

Up to 107 cases were processed in the Neuropatho- Research projects
logy laboratory during 2018, with the following distri-
bution depending on the origin (see right) "Use of hyperoxia combined with vasculature nor-
malizing agents for the treatment of Alzheimer's di-
According to these data, the number of donation sease, a proof of concept." Project funded by the
cases extracted and processed entirely in the UIPA Domingo Martínez Foundation. Principal investiga-
in 2018 amounted to 73, which is slightly lower than tor: Alberto Pascual, Sevillle Biomedicine Institute

CIEN Foundation Annual Report 2018 / 54