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tive recruitment. In particular, people
who are socially disadvantaged are less
likely to participate in that research.
The integration of neuroscience with
population studies and neuroscientific
epidemiological approaches is of vital
importance and provides the opportu-
nity to integrate the understanding of
brain health, neurobiology, and neuro-
pathology within the general popula-
tion to support better prevention, care
and cure of dementia.
The main objective of the popula-
tion-based study "Vallecas Project" for
Early Detection of Alzheimer's Disea-
se, is to elucidate, through tracking of
progression, the best combination of
clinical parameters and complemen-
tary tests (imaging and laboratory)
that allow deciphering at medium-
and long-term features that distingui-
sh those who will develop memory
impairment (MCI and dementia) from
those who will not. Thus, it intends to
identify various markers to determine
eventually the potential risk that each
individual could have to develop the
disease in the future.
4.2 Background: Pilot project
A pilot study was conducted between
June 2010 and February 2011, prior to
the final project, whose first prelimi-
nary results are presented in this re-
port. The aims of this study were:
• To verify the feasibility of
Cien Foundation annual report 2020
the working procedure, the
cooperation of the target
population and the adequacy of
screening protocols to the study
objectives.
• To obtain early and sufficient
information on the characteristics
of the recruited volunteers and
those that could not be recruited,
as well as the limitations of the
actual sampling compared to the
intended one.
• To get experience in the
implementation of the different
elements of the protocol and
to estimate the burden of the
evaluator and the evaluated.
• To promote the Project to achieve
the participation of volunteers and
attracting enough funds to carry
out the Vallecas Project.
• 175 volunteers were involved in this
phase of the project, of which:
• 95 people were able to participate
in the project.
• 80 people were unable to
participate because they met at
least one exclusion criterion.
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