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• “BP28248” A Phase III, multicenter, randomized,                                       Team
   double-blind, parallel group, placebo-
   controlled trial to investigate the safety and      The Department of Neuroimaging team, led by Dr.
   eficacy of RO4602522 added to background            Bryan Strange (MD, PhD, Clinical Neuroscience), has
   therapy with acetylcholinesterase inhibitors,       a highly multidisciplinary nature and consists of the
   donepezil or rivastigmine in patients with          following personnel:
   moderate Alzheimer's Disease". Protocol Nº BP
   28248, Promoter F. Hoffmann-La Roche Ltd.                                    Research fellows

During 2015 the acquisition of MR images from a        Alba Sierra-Marcos
total of 963 subjects has been completed. Overall,     (MD, Neurology).
5,744 MRI studies have been performed distributed      Dr. Christopher Long
among the different research projects.                 (PhD, Engineering, Specialist in Biomecial
                                                       Imaging, Madrid-Massachusetts Institute of
A total of 43,864 MRI sequences have been con-         Technology Vision Program).
ducted since the creation of the department, distri-   Eva Dueñas Moreno
buted by year and type of sequence.                    (BSc, Biology). Since December 2015.
                                                       María Molina Matas
                       Provision of services           (BSc, Physics). Since December 2015.

The Department of Neuroimaging has a 3T MR scan-                            Radiodiagnostics
ner (GEHC, HDxt) system equipped with dual gra-
dient system of up to 50mt/m, 3 antennas for brain     Mabel Torres Llacsa (MD, Radiodiagnostics).
studies (transmitter/receiver quadrature antenna, re-
ceiving 8 channels antenna and 16 channels recei-                          Image Acquisition
ving antenna) and small antennas for rats and mice.
Data is stored in PACS with direct recovery capacity   Eva Alfayate Sáez
for five years of work.                                (Technical Coordinator Técnico in
                                                       Radiodiagnostics).
For Functional MRI studies the Department has an       Felipe García Fernández
audio/video system compatible with 3T MRI. A va-       (Advanced Technician in Diagnostic Imaging).
riety of software packages is used, mainly SPM12       Carmen Rojas Obregón
and FSL.                                               (Technician in Radiodiagnostics).

                             Sequences                                        Administration

Image acquisition of 3D isotropic studies with T1 se-  Arantza Narciso
quences for VBM. Image acquisition of T2 sequen-       (Administrative Assistant).
ces, DWI, ASL, BOLD and spectroscopy.                  Corina Ghinea
                                                       (Administrative Assistant).

CIEN Foundation Annual Report 2015 / 50
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