Page 52 - Memora anual Fundación CIEN 2015
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Among the funded research projects in this area the • Complete genome analysis of 'splice' variants in
following can be highlighted: Huntington's disease. Principal Investigator: José
Javier Lucas Lozano (Centro de Biología
• Age-associated Alzheimer's pathology profile Molecular "Severo Ochoa", CSIC).
(The 85+CIEN Study). Project funded by FIS,
2013-2015. Provision of services
The segment of population over 85 years is the one The range of activities undertaken by the depart-
with the highest relative growth in recent decades ment derives from the ability of its members to co-
and will increase even more in the next, especially in llect, process, evaluate and diagnose brain tissue
Spain, which will become the country with the oldest sample from human or animal origin.
population in the European Union. Several contro-
versies have focused in recent years the study of de- • Neuropathological autopsies of donors brain
mentia and healthy cognitive profile in these tissue, from both the Region of Madrid, as
population group. Overall, clinical and pathological neighboring Regions.
studies suggest that Alzheimer's disease shows spe-
cific clinical, neuropathological and genetic be- • Management of a biobank of neurological
yond age 85, with greater involvement of vascular samples. Transfer of samples to researchers
pathology and similar phenomena are observed in according to the BT-CIEN standard operating
other neurodegenerative disorders (synucleinopa- protocols.
thies, tauopathies). This project aims to address this
set of issues in a large series of post-mortem brains • Diagnostic consultations of neuropathological
from donations to four biobanks from three Spanish cases. Among the external consultations those
Regions. More than 500 brains with associated basic made in support of other neurological samples
clinical information, and in a proportion of cases (75 biobanks (Murcia, Salamanca and Cordoba)
estimated cases) with detailed cognitive data from can be highlighted.
their last year of life, will be studied. Clinical, neuro-
pathological, neuropsychological gathered will be • Perfoming neurohistological and
analyzed according to the main diagnostic groups, immunohistochemical techniques in
associated pathologies, observed stages in the dif- neurological samples of human and
ferent diseases and age groups at death and at di- experimental origin.
sease onset. Clinical-pathological correlation of
findings in relation to dementia in the subgroup of • Evaluation of new antibodies in human brain
cases with cognitive tracking information will be tissue.
analyzed. Results will provide a neuropathological
and clinical-pathological profile of cognitive disor- • Collaboration in research projects from other
ders observed in tissue donors, particularly in cases institutions
of the oldest-old.
CIEN Foundation Tissue Bank (BTCIEN)
The Department also participates in the project
below, funded by BBVA Foundation: Since its opening in May 2010, the CIEN Foundation
Tissue Bank (BT-CIEN) has traveled a path of growth
and consolidation in the field of Spanish Neuros-
cience, supporting national and international rese-
arch groups and maintaining close contact with
neurological disease patients and relatives associa-
tions.
CIEN Foundation Annual Report 2015 / 54
