Page 57 - Memora anual Fundación CIEN 2015

3. SCIENTIFIC ACTIVITY

The CAFRS takes care of 156 patients in residence, tocols of the biobank. The total number of samples
and 40 patients in the Day Centre. incorporated to the BT-CIEN so far, corresponding to
the Alzheimer project monitoring program, adds up
The Alzheimer project monitoring program includes to 2,084 (13.7% patients corresponding to the Day
obtaining a blood sample biannually coinciding with Centre), which have resulted in a total of 29,176 ali-
the one routinely performed at the Center for con- quots.
ventional analytics. Thus, performing a venipuncture
in the patient for research purposes only is avoided. Consistent with other studies, the analysis of the
After extraction, each blood sample is processed at APOE gene polymorphism in CAFRS patients revea-
once, resulting in 14 aliquots comprising various he- led a high presence of allele ε4, that in this popula-
matologic derivatives (whole blood, plasma, serum, tion appears to be more prevalent in men. Also, the
etc.), including extraction of DNA for genetic studies. phenomenon of advancement of the age of onset
of Alzheimer's disease associated with the ε4 allele,
Aliquots obtained from blood samples are incorpo- observed in other cohorts, is noted as it is the reverse
rated into the CIEN Tissue Bank (BT-CIEN, for its phenomenon of delayed age of onset associated
acronym in Spanish) collection according to the pro- with the ε2 allele.

Samples obtained up to December 31, 2015 according to the number
of semiannual evaluations

239

211
196

165 Residence Day care center
149

Samples 124 118
106 107

91 97

61 67 62 54 56
45

32 33

23 15 6 13
0 0 10
5 3 2 1 1 0 0

1ª 2ª 3ª 4ª 5ª 6ª 7ª 8ª 9ª 10ª 11ª 12ª 13ª 14ª 15ª 16ª 17ª

Evaluation

CIEN Foundation Annual Report 2015 / 59