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investigators are Drs. Miguel Medina and Miguel Ca- duals (elderly volunteers) within the Vallecas Project,
lero. The main objective of this proposal is to explore as well as patients with confirmed AD after autopsy.
the possible role of miRNAs and markers of lipid me- To this end, we propose to carry out a complemen-
tabolism as possible links between peripheral vascu- tary and synergistic approach to evaluate, validate
lar dysfunction and the pathophysiology of AD. The and standardize the identification, monitoring,
design of the project is based on a double appro- quantification and functional validation of miRNAs
ach with complementary aims related to the existing in plasma samples taken from elderly subjects who
cohorts (Vallecas Project and Research Program of are cognitively normal, show deterioration cognitive
the Vallecas Research Center (PICAV) and the CIEN mild or moderate dementia, in the presence or ab-
Foundation Brain Bank. The central working hypo- sence of peripheral vascular pathology. Following a
thesis builds upon the existence of circulating miR- multidisciplinary approach, the analysis of the data
NAs and molecules of lipid metabolism in plasma obtained will benefit from the availability of other
that could differentiate cognitively normal indivi- data generated within the Vallecas project (socio-
duals from people with mild cognitive impairment or demographic data, clinical history, annual neurolo-
dementia, either alone or in combination with other gical evaluation, neuropsychological evaluation,
parameters being collected from the same indivi- structural and functional brain MRI, genotyping, etc.)
Samples obtained up to December 31, 2017 according to the number of semiannual evaluations
311
278
235 Residence Day Care Center
196
184
Samples 155
138
119 124 120
83
91 73
63 73 66 64
43 42 35 32 26
30
22 16
11 2 0 03 0
1ª 2ª 3ª 4ª 5ª 6ª 7ª 8ª 9ª 10ª 11ª 12ª 13ª 14ª 15ª 16ª 17ª 18ª 19ª 20ª
Evaluation
CIEN Foundation Annual Report 2017 / 80
