Page 62 - Annual Report 2018

projects), whose main investigators are Drs. Miguel
Medina and Miguel Calero. The main objective of
this proposal is to explore the possible role of miRNAs
and markers of lipid metabolism as possible links bet-
ween peripheral vascular dysfunction and the pa-
thophysiology of AD. The design of the project is
based on a double approach with complementary
aims related to the existing cohorts (Vallecas Project
and Research Program of the Vallecas Research
Center (PICAV) and the CIEN Foundation Brain Bank.
The central working hypothesis builds upon the exis-
tence of circulating miRNAs and molecules of lipid
metabolism in plasma that could differentiate cog-
nitively normal individuals from people with mild
cognitive impairment or dementia, either alone or in
combination with other parameters being collected
from the same individuals (elderly volunteers) within
the Vallecas Project, as well as patients with confir-
med AD after autopsy. To this end, we propose to

Distribuon of APOE genotypes
in the CAFRS paents cohort

APOE genotypes
ε2/ε3
ε2/ε2
19
0 5% ε2/ε4
ε4/ε4 0% 5
35 1%
8%

ε3/ε3
ε3/ε4 207
164 48%
38%

CIEN Foundation Annual Report 2018 / 62