Page 118 - Libro Memoria Cien Inglés
P. 118
Vallecas Project will be very useful in healthy people, lacks data that allow
both projects. The data obtained in the confirming the disease as CSF or PET
survey on COVID-19 affectation carried image markers. Therefore, the incorpo-
out in two waves during the first mon- ration of informative biomarkers in
ths of 2020, accepted for publication in blood such as Aß40, Aß42, tau or Nf-L
the journal Gerontology, is being exa- will be of vital importance to streng-
mined for possible integration with then the Vallecas project, allowing us
those of the ACE Foundation of Barce- to increase the validity and impact of
lona and the exploration of genetic the research results. Using data from
polymorphisms as risk factors for this volunteers who have converted to MCI
disease. Finally, it should be noted that between visit 1 and visit 2, the Depart-
a project has been submitted to La ment of Neuroimaging has developed
Caixa's call to study in the Vallecas an algorithm capable of predicting the
Project cohort the late neurological development of Mild Cognitive Impair-
sequelae of SARS-CoV-2 infection and, ment (MCI) in previously cognitively
more specifically, its eventual effect on healthy elderly. This algorithm based
the neurodegenerative process of solely on the verbal memory score and
Alzheimer's disease. If approved, work the density of gray matter in the entor-
would begin in the third quarter of hinal cortex has made it possible to
2021. During 2021, the launch of a new predict the conversion to MCI with
platform based on new ultrasensitive high precision. The application of this
technologies for the detection of bio- algorithm to the analysis of people
markers in biological fluids useful in who convert to MCI on subsequent
the early diagnosis of neurodegenera- visits has also shown high precision in
tive diseases is expected. The acquisi- a group of individuals different from
tion of new equipment with this tech- the discovery group, thus allowing its
nology based on digital ELISA for the applicability to be validated. These
detection of single molecule will allow results have been sent for publication
the establishment of the necessary to the journal Science Advances, and
procedures for its implementation following the comments of the re-
during the first months of the year. In viewers, during 2021, we will comple-
the context of the CIEN Foundation, ment these findings with data on
the acquisition of a highly sensitive Alzheimer's disease pathology confir-
peripheral biomarker analysis platform med by plasma biomarkers in the
is considered especially relevant for the converter groups (currently in process).
enhancement and better use of the In addition to examining memory
Vallecas Project, as well as other Foun- decline (in MCI converters), the Depart-
dation projects. The Vallecas Project, ment of Neuroimaging is studying
due to its own exploratory nature in Vallecas participants with extraordi-
Cien Foundation annual report 2020 118
