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varied information to examine the developing cognitive impairment. The
initial phases of cognitive decline in course of cognitive performance ob-
this cohort and to support new pro- served in these subjects over 4-5 years
jects based on the data, biological will also be studied to identify sub-
samples and images accumulated in groups with different evolution and
an extensive database whose curation prognostic relevance. Likewise, with
and exploitation is a continuous task. the data obtained in the neuropsycho-
The analysis of the data obtained so far logical evaluations of the subjects who
and systematically collected in the have not shown any cognitive impair-
project's database has led to several ment during the entire follow-up,
research studies, some of which have normality standards will be established
already been published and others are that will be of great use in clinical
pending of publication or being con- practice for the diagnosis of cognitive
cluded. In particular, the effect of va- impairment in the Spanish population.
rious drugs on cognitive impairment, During the first months of 2021, the
subjective cognitive complaints and project entitled "MicroRNAs and lipid
prior cognitive reserve has been exa- metabolism markers as a potential link
mined, and the effect of some patho- between vascular dysfunction and the
logies, such as diabetes or sleep disor- pathophysiology of Alzheimer's disea-
ders, is being examined. These studies se" will be completed, the main objec-
will also consider the concomitant tive of which is to explore the possible
effect of some of the biomarkers (ge- role of miRNAs and metabolism mar-
netic, biochemical and neuroimaging) kers of lipids as possible links between
that have been collected to characteri- peripheral vascular dysfunction and
ze the population at higher risk of AD pathophysiology. Likewise, a pro-
Cien Foundation annual report 2020 116
