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samples. project database. Text reports have
been encoded, incorporating each
• Structural Study (3D item to the database, as well as atta-
volumetry, T2 and FLAIR)
ching the report of each visit in pdf
Determining the progressive loss of format, enabling viewing, and down-
brain volume during aging, especially loading to all researchers who have
in white matter provides volumetric access to the database.
quantitative indexes of the morpho- On the other hand, we have organized
logical aging-associated changes. MRI data corresponding to the 'Valle-
In this sense, the VBM (Voxel-Based cas Project' and Queen Sofia Founda-
Morphometry) techniques, based on tion Alzheimer Center subjects, con-
creating statistical comparisons of gray verting the data obtained directly from
and white matter patterns constitute MRI equipment into the appropriate
the method of choice, and allows us to format for analysis.
determine the volume reduction of the
amygdala, hippocampus, entorhinal A collaborative project with CESVIMA
cortex, etc. (Supercomputing and Visualization
Center of Madrid), a center from the
• Diffusion Study (b: 800)
UPM (Technical University of Madrid)
White matter, partly due to Wallerian has also been established.
degeneration and partly to reduced As a result, a VBM analysis of T1 se-
connectivity by decreased cortical ac- quences from visits 1 and 2 of the sub-
tivity, presents ultrastructural changes jects 'Vallecas Project' has been perfor-
that can be detected with diffusion med. The results of this analysis form
techniques (DTI).
the basis of a new project awarded to
• Brain Perfusion Study Dr. Bryan Strange by the Alzheimer's
Association ("The healthy elderly brain:
Cerebral perfusion related to cortical MRI predictors for developing MCI"),
activity may be assessed -without nee- which has allowed the hiring of a new
ding to inject contrast-through MR se- team member, Dr. Linda Zhang. Dr.
quences (Arterial Spin Labelling, ASL) Zhang, expert in analysis of structural
and therefore hypofunctioning areas MR images, has examined the white
will present decreased perfusion. matter in visit 1 of the subjects of the
Vallecas Project.
Throughout 2015 all Neuroradiology
reports from every subject and each In 2020, Dr. Linda Zhang continued
of the visits from the 'Vallecas Project' working on the predictive algorithm
have been incorporated in the single in Dr. Jussi Tohka's laboratory at the
Cien Foundation annual report 2020 112
