Page 117 - Libro Memoria Cien Inglés
P. 117
ject that continues this line of research Project cohort, we have collaborated
will begin, entitled “Molecular mecha- with various researchers and the con-
nisms associated with risk factors and tributions of doctorate and master’s
resilience in neurodegeneration. Lipid students has been collected. Likewise,
metabolism and membrane dynamics the integration of data from the Valle-
(NeuroRisk)”. The general objective of cas Project with those of other national
this proposal is to explore the molecu- and international cohorts has been
lar and cellular mechanisms that con- facilitated. The most outstanding
fer susceptibility or resilience to the collaboration of this type has been the
appearance and progression of AD and participation in a large genetic study in
related disorders, focusing on the collaboration with the Dementia Gene-
interaction of lipid metabolism and tics Consortium (DEGESCO) and the
membrane dynamics with the transce- European DNA Bank, which has led to
llular spread of pathognomonic prote- results of high impact and scientific
ins such as tau, in the brain. This pro- and clinical interest on the genes
ject, like the previous one, benefits involved in the pathophysiology of spo-
from a design conceived with a double radic Alzheimer's disease. These colla-
approach with complementary objec- borations have facilitated the genetic
tives related to the cohorts of the characterization of all volunteers inclu-
Vallecas Project, and the residence of ded in the Vallecas Project, which may
the Queen Sofia Foundation Alzhei- be of great value in future studies.
mer’s Center. Following an interdiscipli- These collaborations will continue to
nary approach, the analysis of the data be promoted during 2021, the year in
obtained in this project will benefit which collaborative works of these
from the availability of other data consortia are expected to be published
generated within the Vallecas Project in high-impact journals. Collaboration
(sociodemographic data, medical has been agreed with a group from
history, annual neurological evaluation, the IMDEA Research Institute Food &
neuropsychological assessment, struc- Health Sciences Center in two research
tural and functional brain MRI, genoty- projects for which funding has been
ping , etc.) in order to identify molecu- requested. If this is achieved, the pa-
lar (biomarker, genetic), clinical, or thophysiological relevance and diag-
neuroimaging signals that can serve to nostic utility of the characterization of
define populations at higher risk of extracellular vesicles that can be isola-
developing dementia later in life. Li- ted in brain, plasma, and other biologi-
kewise, we hope to be able to publish cal media and that show certain speci-
in 2021 the results of the “Vallecas ficity in patients with Alzheimer's
Brain” that has been created. To en- disease will be studied. The clinical
hance the usefulness of the Vallecas data and samples collected in the
