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Department activities impact on the clinical trajectories of
the patients, with special attention
The core activity of the UIPA’s Depart- to disease progression rate and
ment of Neuropathology corresponds survival time (project based mainly
to the BT-CIEN, both to its organizatio- on the patient cohort from the
nal and logistical components as well residency of the Queen Sofia
as the neuropathological diagnostic Foundation Alzheimer's Center
work and the management of biologi- Research Program).
cal samples.
• Pathological role of fungal
The Department also participates in colonization and the polymicrobial
numerous collaborations in external infection of the Central Nervous
research projects, mainly with CIBER- System in Alzheimer-type
NED research groups, and carries out pathology. Risk factors and
its own internal projects, mainly based clinical impact. Impact of
on series of cases from postmortem neuroinflammation associated
donation. Among the active lines of with polymicrobial infection on
research in the Department are the the origin and progression of
following: neurodegenerative pathology.
• Distinctive features of
• Neuropathological and
molecular study of tauopathies, Alzheimer-type pathology in
including Alzheimer's disease. nonagenarians and centenarians.
Pathogenic significance and Neuropathological findings in
spread of associated cellular subjects without cognitive disorder
lesions. Argyrophilic grains above 90 years of age.
disease and other recently • Advance age-associated changes
described tauopathies (PART, in Central Nervous System and
ARTAG) as models of tauopathy cerebral pathology in mammals
with predominant involvement and non-human primates. Search
of the medial temporal lobe. for natural models of Alzheimer in
Lewy pathology limited to the primates and other mammalian
amygdala. Hippocampal sclerosis groups.
and associated TDP-43pathology
(LATE).
• Clinicopathological profiles
in advanced dementia.
Characterization of the combined
and mixed pathology and its
