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new entity with TDP
pathology, LATE
(Limbic-Predominant
age-related TDP-43
encephalopathy), all of
which occur frequently
in combination with the
most prevalent pathologies
that produce dementia in
elderly subjects.
A need for dementia research is the
availability of well-diagnosed, classi-
fied and long-term preserved brain
tissue. Brain banks (biobanks of neuro-
As repeatedly demonstrated in cli- logical samples) respond to this need,
nical-pathological sessions, made and the CIEN Foundation has one of
possible in most cases thanks to the the main brain banks in the country,
donation of brain tissue by patients or the CIEN Tissue Bank (BT-CIEN, for its
their families and the close collabora- acronym in Spanish).
tion of clinicians, the final classification
of a case requires the integration of all Neuropathology also provides signifi-
clinical, neuroradiological, neuropa- cant support for studies based on ani-
thological and molecular information, mal models of neurological diseases,
when available. both for the histological evaluation of
transgenic animals and for the search
Thanks to the joint work of neuropa- for natural models of the disease. The
thologists from various continents, all Department of Neuropathology of the
of them associated with brain tissue CIEN Foundation participates regularly
donation programs, in recent years the in the histological evaluation of animal
precise characterization of histological models of different neurodegenerati-
brain lesions that until now had not ve diseases developed by CIBERNED
been interpreted as defined pathologi- researchers, as well as in the neuropa-
cal entities has been achieved. This has thological study of elderly mammals of
led to the description of new tauopa- the Madrid Zoo.
thies, such as PART (Primary Age Rela-
ted Tauopathy) and ARTAG (Aging-Re-
lated Tau Astrogliopathy) and of a
Annual report Fundación CIEN 2020 74
