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3.2.3. Departament of Neuropathology
Neuropathology of neurodegenerative disorders is a specialty in
continuous progress with capacity for contrasting clinical judg-
ment and performance of any diagnostic test, including the most
recent biomarkers, with the final diagnosis that is still neuropatho-
logy ("gold standard"). However, in the field of basic research, neu-
ropathology plays an additional role, providing critical information
about the molecular components of the characteristic lesions of
each disease, the pathogenic mechanisms, and the potential asso-
ciated biomarkers.
The post-mortem neuropathological findings observed in dona-
tions of brain tissue from patients with neurodegenerative disea-
ses, especially in the case of dementias, have allowed to know in
recent decades the epidemiological reality of these diseases in the
population, and among other evidence, have revealed the high
prevalence of combined pathology (mainly Alzheimer's pathology,
Vascular pathology, Lewy pathology, TDP-43 pathology, various
tauopathies linked to advanced age).
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