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ropathology has been involved in the            since the CIEN Foundation's Tissue
                  following research projects:                    Bank (BT-CIEN) was inaugurated. Until
                                                                  that moment (April 21, 2010), the Al-
                   •  National Biobank Network (RNBB,             zheimer Project biobank (of the Queen
                      for its acronym in Spanish),                Sofia Foundation and the CIEN Foun-
                      Platform funded by ISCIII, 2018-            dation), had focused its activity on
                      2020, which has the BT-CIEN as              the donations of brain tissue from the
                      one of its nodes. Alberto Rábano            Queen Sofia Foundation Alzheimer’s
                      is co-coordinator of Program 3              Center in Vallecas. Thus, since its in-
                      (R+D+i) while Laura Saiz performs           ception, the BT-CIEN has had an inter-
                      tasks to support the Coordination.          nal donation program, aimed at the
                      Within the Program 3research                cohort of patients followed in CAFRS,
                      lines, Ana Belén Pastor participates        and an external donation program,
                      in Working Group 3.2 dedicated              aimed at the general population of the
                      to the study of microRNAs as new            Region of Madrid, and other Regions
                      types of biological sample, and             that at that time did not have a Neuro-
                      Valentina González collaborates in          logical Tissue Bank. The external pro-
                      line 2.1 dedicated to the study of          gram gathered at that time the expe-
                      quality markers in tissue samples           rience and tradition of the Tissue Bank
                      (OPTIMARK multi-center research             for Neurological Research, which had
                      project, funded by FIS, ISCIII).            begun its activity in 1996 at the Faculty
                                                                  of Medicine of the Complutense Uni-
                  Progressive Supranuclear Palsy. Iden-
                  tification of susceptibility loci involved      versity of Madrid.
                  cellularity and molecular pathways for          Within the framework of the regula-
                  drug development. Funding entity:               tions created in our country on biome-
                  CIBERNED (Cooperative projects). Par-           dical research (Biomedical Research
                  ticipating entities: ACE Foundation, H.         Law, 2007 and Royal Decree of Bio-
                  U. Marqués de Valdecilla, Severo Ochoa          banks, 2011), in 2013 the BT-CIEN recei-
                  Molecular Biology Center (CSIC), CIEN           ved the Accreditation of the Ministry of
                  Foundation                                      Health and Social Welfare of the Com-
                                                                  munity of Madrid and was registered
                                                                  in the Biobank Registry of the Carlos III
                                                                  Institute of Health. Likewise, in terms of
                  10 years of BT CIEN activity                    Quality Management, in 2012 BT-CIEN


                  On April 21, it was the 10th anniversary        received the quality certification ISO:
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