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Department activities are decisive for working on the two
main projects of the CIEN Founda-
The activity of the Biochemistry and tion-Queen Sofia Foundation: the
Molecular Genetics Department focu- Vallecas Project for the early detection
ses mainly on the search for biomar- of Alzheimer's disease and the Alzhei-
kers of early diagnosis of Alzheimer's mer's Center of the Queen Sofia Foun-
disease and the study of genetic sus- dation Research Program.
ceptibility factors of AD and other neu-
rodegenerative disorders. This activity • The Vallecas Project
has the following objectives: to deepen
the molecular basis of the disease and It is currently known that the patho-
develop predictive algorithms that logical processes that determine Al-
combine information on genetic and zheimer begin many years before the
biochemical markers with diagnostic, disease leads to the first noticeable
prognostic, or response value to modi- symptoms in patients. Years before
fying therapies. that future drug treatments preven-
ting or slowing down disease progres-
For this purpose, multidisciplinary sion could be applied to the "popula-
research with the rest of the CIEN tion at risk" who has developed these
Foundation departments, together subclinical lesions or has a higher risk
with the CIEN Tissue Bank (BT-CIEN), of developing it than the rest of the
Annual report Fundación CIEN 2020 86
