Page 90 - Libro Memoria Cien Inglés

FOLLOW UP VISIT 1ª 2ª 3ª 4ª 5ª 6ª 7ª 8ª 9ª 10ª 11ª 12ª 13ª 14ª 15ª 16ª 17ª 18ª TOTAL

Residence 0 4 2 7 5 5 3 4 0 3 2 1 2 0 0 0 0 0 184
Day center 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 26

Cumulative 2020

FOLLOW UP VISIT 1ª 2ª 3ª 4ª 5ª 6ª 7ª 8ª 9ª 10ª 11ª 12ª 13ª 14ª 15ª 16ª 17ª 18ª 19ª
Residence 349 324 283 241 229 183 157 146 141 131 99 89 74 68 45 39 35 27 202
Day center 133 102 77 58 44 29 15 10 6 4 4 4 3 1 1 1 0 0 26
Samples obtained up to December 31, 2020 according to the number of semian-
nual evaluations. Above: samples obtained in 2020. Below: samples accumulated
since the beginning of the CAFRS Research program

Consistent with other studies, the analysis of the APOE gene polymorphism in CA-
FRS patients revealed a high presence of allele ԑ4, which in this population appears
to be more prevalent in men. In addition, the phenomenon of advancement of the
age of onset of Alzheimer's disease associated with the ԑ4 allele observed in other
cohorts, is noted, as it is the reverse phenomenon of delayed age of onset associa-
ted with the ԑ2 allele.

APOE GENO- n
TYPES
e2/e2 0

e2/e3 19
e2/e4 5
e3/e3 214

e3/e4 168
e4/e4 35

Distribution of APOE genotypes in the CAFRS patients cohort

Annual report Fundación CIEN 2020 90