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• Molecular mechanisms vestigators. Its general objective is
associated to risk factors and to explore the molecular and cellular
resilience in neurodegeneration. mechanisms that confer susceptibility
Lipid metabolism and membrane or protection/resistance to the onset
dynamics (PID2019-110401RB-100) and progression of Alzheimer's disease
(AD) and related disorders, focusing on
This project has been funded by the the interaction of lipid metabolism and
MICINN and has Drs. Miguel Medina membrane dynamics with the transce-
and Miguel Calero as Principal In-
llular spread of pathognomonic pro-
teins in the brain. For this purpose, we
will analyze physiological and patholo-
gical brain aging, focusing specifically
on apolipoprotein-mediated modula-
tion in the spread of neurofibrillary tau
pathology and amyloid pathology. Our
working hypothesis is based on the
idea that lipid metabolism and mem-
brane dynamics (and more specifically
ApoE as a key regulator of cholesterol
homeostasis) are common elements
that regulate the onset and progres-
sion of different neurodegenerative
diseases. Therefore, our objective is
to study the risk and protective/resi-
lience factors that contribute to the
development of the disease or brain
resilience in advanced ages. To do this,
we propose three interconnected and
complementary objectives in order to
address the study of potential mole-
cular pathways that underlie the me-
Annual report Fundación CIEN 2020 92
