Page 89 - Libro Memoria Cien Inglés

• Queen Sofia Foundation Alzheimer extraction of DNA for genetic studies.
Center Research Program
Aliquots obtained from blood sam-
The Queen Sofia Foundation Alzhei- ples are incorporated into the CIEN
mer Center Research Program focuses Tissue Bank (BT-CIEN, for its acronym
on regular and protocol-based monito- in Spanish) collection according to
ring of a cohort of CAFRS patients with the protocols of the biobank. The total
dementia, ether as residents at the number of samples incorporated to
Center or attendants at the Day Cen- the BT-CIEN so far, corresponding to
ter, with the main objective of investi- the Alzheimer project monitoring pro-
gating the final stages of Alzheimer's gram, adds up to 3,412 (15.2% patients
disease. A family member or guardian corresponding to the Day Centre),
recruits patients into the monitoring which have resulted in a total of 47,768
program after signing an Informed aliquots of different fractions derived
Consent. The Alzheimer Project pro- from blood samples.
gram consists of i) a biannual clinical
and neuropsychological assessment
by the Multidisciplinary Support Unit
(UMA. for its acronym in Spanish), ii) a
biannual blood sampling, coincident
with the usual one taken at the resi-
dence, iii) conducting an annual cranial
MRI if the patient's condition allows it,
and iv) donation of brain tissue after
patient's death.

The CAFRS takes care of 156 patients in
residence, and 40 patients in the Day
Centre. The Alzheimer project-moni-
toring program includes obtaining a
blood sample biannually coinciding
with the one routinely performed at
the Center for conventional analytics.
Thus, performing a venipuncture in the
patient for research purposes only is
avoided. After extraction, each blood
sample is processed at once, resulting
in 14 aliquots comprising various he-
matologic derivatives (whole blood,
plasma, serum, etc.), including