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2.4.1 Research projects                          •  The Vallecas project


                  The CIEN Foundation was created with             •  BT-CIEN Tissue Bank.
                  the aim of promoting the foundation              •  Alzheimer Program
                  of a network center that supports,               •  Other research projects
                  promotes, and coordinates research
                  activities. The objectives of the CIEN           •  Service provisions
                  Foundation are specified in six funda-           •  Training
                  mental activities:






                  Vallecas Project: Research aimed at identifying individuals with a higher risk of
                  developing Alzheimer's type dementia (AD), based on the combination of socio-
                  demographic, clinical, neurological, neuropsychological, genetic, biochemical and
                  neuroimaging data, within the framework of the project called “Vallecas-2, early
                  detection of Alzheimer's disease. Risk and protection factors”. The Queen Sofia
                  Foundation, signatory of the agreement dated on February 14, 2018, undertakes to
                  contribute during each of the 4 years of planned duration of the project, the suc-
                  cessive amounts that are agreed annually by its Board of Trustees, corresponding
                  to the first three years a total amount of € 300,000.00.


                       YEAR                                 2018        2019         2020
                       Queen Sofia Foundation Contribution  300.000,00  300.000,00   300.000,00



                  The Vallecas Project is one of the main         Bank). Contributions to BT-CIEN come,
                  research projects carried out by the            in addition to those obtained in the
                  CIEN Foundation, both in terms of               CAFRS (Internal Donation Program),
                  resources used and its social impact. In        from donors from the Community of
                  parallel, the CIEN Foundation is enga-          Madrid and other Regions (External
                  ged in other research projects on neu-          Donation Program). In turn, the BT-
                  rodegenerative diseases, among which            CIEN, after processing, diagnosis and
                  the Alzheimer Center Project and the            classification, maintains the biological
                  Biobank Platform stand out.                     material in long-term archive condi-
                                                                  tions and distributes it to researchers
                  Tissue-Bank (BT-CIEN): Through the              and institutions that require it for
                  Department of Neuropathology of the             research projects, in accordance with
                  CIEN Foundation, a biobank of neuro-            the application and transfer of biobank
                  logical tissue is managed (CIEN Tissue
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