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differences. subjects and individuals with SCI-
• A comprehensive protocol Plus with respect to the pattern
proposal for collecting SCI -related of brain connectivity (a greater
information has been described hyperconnectivity associated with
and published. An operational SCI-Plus would be expected, as
definition has also been provided to the literature has already shown
classify individuals into the above in later phases of mild cognitive
three groups, namely non- SCI, SCI impairment).
and SCI Plus. Usefulness of various cognitive para-
• An opinion paper has been meters as early markers. Numerous
published related to the need studies have shown that there are
to demonstrate that the SCI certain cognitive variables that allow
classification is stable over time. the identification of subjects at higher
This is a prerequisite to be able to risk of developing Alzheimer's disease
consider SCI as a variable of interest years before their diagnosis. With this
in the field of early detection of MCI. idea in mind, we investigate whether
certain parameters of the neuropsy-
• Our results have shown that
when an assessment protocol is chological protocol, in the context of
used systematically and rigorous a longitudinal research project such
operational criteria are employed, as the Vallecas Project, are useful to
the SCI classification is sufficiently identify individuals at risk of cogni-
stable. tive impairment. These parameters
are analyzed in an evolutionary way
• After analyzing the temporal together with the rest of clinical and
dynamics of the DCS groups during genetic information of each volunteer
3 years, the following sequential to obtain a classification algorithm that
transition is observed that fits could eventually be generalized to dai-
perfectly with the hypothesis of ly clinical practice.
the different stages of AD: non-
SCI SCI SCI-Plus MCI. The risk of In addition, the Clinical Department is
developing MCI therefore increases interested in developing new assess-
progressively in the SCI and SCI- ment tools that allow examining the
Plus groups respectively. role of other cognitive markers not
studied in standard neuropsychologi-
• Our future interest is to combine cal evaluations. It is expected that the
the available cognitive data with identification of these markers increa-
fMRI data. The objective is to ses sensitivity and specificity when
determine if there are significant detecting individuals at risk of demen-
differences between control
tia. Among the most important results
Annual report Fundación CIEN 2020 56
