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individuals. These interventions can relatives of AD patients: assessment
be carried out both in healthy elderly of the influence of an intervention and
people, in order to prevent the onset SCI" (RTI2018-098762-B-C31) funded by
of cognitive impairment, as well as in the Ministry of Science, Innovation and
patients with cognitive impairment, to Universities through the Research Cha-
try to modify the course of the disease. llenges call 2018 of the R+D+i National
Among the most used non-pharmaco- Plan. Specifically, within this project
logical interventions, changes in lifes- the department of neuropsychology
tyle, especially regarding diet, physical leads the subproject entitled “Elderly
exercise, and cognitive training stand Relatives of Alzheimer Disease (ERAD):
out. influence of the Subjective Cognitive
Decline”.
Although scientific evidence has
shown that non-pharmacological the- Spatial analysis of changes in retinal
rapies have a protective effect against layer thickness in Alzheimer's disease
cognitive impairment, there are still and other neurodegenerative disor-
some unresolved issues related to this ders. In collaboration with the Institute
topic. For example, determine what of Knowledge Technology of the Com-
type of intervention is most beneficial plutense University of Madrid and the
or what clinical variables are associated ACE Foundation, a series of studies on
with a better prognosis of the therapy. the retina, the most accessible part of
Taking advantage of the knowledge the central nervous system, have been
accumulated throughout the Vallecas initiated using the optical coherence
Project, the objective of the Depart- tomography technique and the appli-
ment of Neuropsychology is to study cation of advanced data analysis tools.
the impact that these non-pharmaco- It is expected to obtain early and speci-
logical interventions have on subjects fic retinal markers of Alzheimer's disea-
at risk of developing mild cognitive se that may be useful for its diagnosis
impairment. Thus, the department is and follow-up with a technique that is
associated to a consortium made up easy to apply and very low cost.
of various research groups from the
Complutense University of Madrid Registry of cases with Mild Cognitive
(UCM, for its acronym in Spanish), the Impairment with biological samples
technical University of Madrid (UPM, (blood and CSF). In collaboration with
for its acronym in Spanish) and the San the Service of Neurology from the In-
Carlos Clinical University Hospital of fanta Leonor Hospital, a registry of ca-
Madrid through the joint research pro- ses with mild cognitive impairment will
ject "Study of the functional connecto- be created in which clinical data and
me modulations in young and elderly biological samples will be systemati-
cally collected to facilitate their future
Annual report Fundación CIEN 2020 60
