Page 57 - Libro Memoria Cien Inglés
P. 57

obtained over the years in this line of          •  •  A pilot study has been carried
                  research, the following are noteworthy:             out with an attentional blinking
                                                                      task among the subjects of the
                   •  Cognitive, tests and in particular,             Vallecas Project. The attentional
                      the Free and Cued Selective                     blink task is a classic paradigm in
                      Reminding Test (FCSRT) verbal                   Experimental Psychology whose
                      episodic memory test, are the                   use has not been extended to
                      most sensitive tools for identifying            clinical samples. It allows obtaining
                      subjects at risk of conversion to               first-order cognitive parameters
                      MCI. Its discriminating capacity is
                      above other variables of interest
                      such as APOE genotyping.
                   •  The predictive capacity of the
                      FCSRT has been shown to be
                      high even in a 4-year follow-up.
                      Especially useful is the parameter
                      of immediate free recall, in which
                      an individual's score below 18 is
                      considered risk for conversion in
                      the next 4 years.

                   •  Processing speed (i.e., mental
                      agility) is another cognitive
                      parameter that has been revealed
                      as an early marker of interest for
                      MCI although we still need to
                      carry out additional analysis in this
                      regard.

                   •  The analysis of the possible effect
                      of drugs on cognitive performance
                      in the Vallecas Project cohort has
                      been examined. The two-year
                      cross-sectional and longitudinal
                      results have not identified any
                      effects of interest and, when any
                      association has been found, it is
                      inseparable from the underlying
                      pathology of the drug itself.
   52   53   54   55   56   57   58   59   60   61   62