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by the cognitive reserve in modifying analyzes different variables associated
the course of different neurodegenera- with cognition, health, lifestyles, and
tive pathologies, including Alzheimer's brain structure in two cohorts of peo-
disease. Likewise, the socioeconomic ple over 90 from Madrid and Braga.
status associated with a person's area
of residence can be understood as an This research program is led by the
environmental factor that determines CIEN Foundation and it includes re-
to some extent the probability of de- searchers from four different institu-
veloping a possible cognitive impair- tions in Spain (CIEN Foundation, Ma-
ment. drid Health Autonomous Organization,
Complutense University of Madrid, and
The interest of the Department for this Biomedical Technology Center), Portu-
construct focuses on analyzing diffe- gal (University of Minho), and Denmark
rent variables that apparently have the (University of Southern Denmark).
capacity to confer cognitive reserve
and therefore could play a protective The results of PILEP+90 will allow ob-
role against cognitive impairment. taining reliable data on the prevalence
Within the Vallecas Project, this set of of cognitively healthy and cognitively
variables is being studied individually impaired long-lived people, as well as
and as groups, with special emphasis validating a battery of clinical tests to
on the activities of daily life performed study the elderly. In addition, thanks
during mid-life. Likewise, different to the combination and exploitation
variables of lifestyle are examined to through machine learning techniques
classify them as risk or protective fac- of demographic, lifestyle, clinical, cog-
tors against the appearance of demen- nitive and neuroimaging data collec-
tia. The results have shown that both ted in the study, PILEP+90 is expected
the variables associated with the indi- to help delay the effects of cognitive
vidual socioeconomic level and those aging, to reduce the risk of developing
associated with the neighborhood of dementia, promote the level of func-
residence play a complementary role tional independence and increase the
in the conversion to cognitive impair- quality of life of all older people
ment. Study of non-pharmacological thera-
pies for the prevention and modifica-
Spain-Portugal Longevity Research
Program (PILEP + 90). PILEP + 90 is a tion of the course of Alzheimer's disea-
research project designed to examine se. Non-pharmacological interventions
the role of biological and environmen- have usually three specific objectives:
tal determinants associated with lon- to stimulate cognitive processes, pro-
gevity and, more specifically, demen- mote the level of autonomy and, ulti-
tia-free longevity. For this, the study mately, increase the quality of life of
